It is 1994, and in the desert near Tillman, Arizona, forty miles from Tucson, a grand experiment involving the future of humanity is underway. As climate change threatens the earth, eight scientists, four men and four women dubbed the "Terranauts," have been selected to live under glass in E2, a prototype of a possible off-earth colony. Their sealed, three-acre compound comprises five biomes—rainforest, savanna, desert, ocean, and marsh—and enough wildlife, water, and vegetation to sustain them.

Closely monitored by an all-seeing Mission Control, this New Eden is the brainchild of ecovisionary Jeremiah Reed, aka G.C.—"God the Creator"—for whom the project is both an adventure in scientific discovery and a momentous publicity stunt. In addition to their roles as medics, farmers, biologists, and survivalists, his young, strapping Terranauts must impress watchful visitors and a skeptical media curious to see if E2’s environment will somehow be compromised, forcing the Ecosphere’s seal to be broken—and ending the mission in failure. As the Terranauts face increased scrutiny and a host of disasters, both natural and of their own making, their mantra: "Nothing in, nothing out," becomes a dangerously ferocious rallying cry.

Told through three distinct narrators—Dawn Chapman, the mission’s pretty, young ecologist; Linda Ryu, her bitter, scheming best friend passed over for E2; and Ramsay Roothorp, E2’s sexually irrepressible Wildman—The Terranauts brings to life an electrifying, pressured world in which connected lives are uncontrollably pushed to the breaking point. With characteristic humor and acerbic wit, T.C. Boyle indelibly inhabits the perspectives of the various players in this survivalist game, probing their motivations and illuminating their integrity and fragility to illustrate the inherent fallibility of human nature itself.